Dihydroquercetin is not medicine.
ITEM |
SPECIFICATION |
ANALYSIS RESULT |
CONFORMITY |
ANALYSIS REFERENCE SOURCE |
|
Appearance, Color, Odor, Taste |
Light yellow solid crystalline powder, characteristic aromatic odor,
astringent |
Yellowish, fine crystalline powder, characteristic aromatic odor, mild
bitter with sweetly aftertaste |
Conforms |
By Manufacture – Visual, Organoleptic |
|
Particle size |
NLT 90% (through 80 mesh) |
NLT 90% (through 80 mesh) |
Conforms |
80 mesh screen / USP/NF<429> |
|
Bulk Density |
0.3 to 0.6 |
0.3 to 0.6 |
Conforms |
USP/NF<699> |
|
Characteristic Values |
Over 85%
Dihydroquercetin |
Over 85% Dihydroquercetin |
Conforms |
HPLC system with reversed phase column and UV detector is
used for peak separation and quantitation. Journal of chromatography, 605:
pp. 41-48 (1992) |
|
Assay
(HPLC λmax 290 nm,
retention time 9-11 minutes) |
94-96% |
95.89% |
Conforms |
Method: ALC114A |
|
Assay
(HPLC λmax 340 nm,
retention time 9-11 minutes) |
92% |
92.10% |
Conforms |
Method: ALC114A |
|
Other Flavonoids:
Dihydrokaempferol, Quercetin,
Naringenin (HPLC λmax 290 nm) |
<10% |
Total: 3.96%
(Dihydrokaempferol-3,5%,
Quercetin -0.5%, Naringenin – 0.1% |
|
Method: ALC114A |
|
Total saponins (UV-Vis) (triterpene
glycosides) |
<10% |
1,3 % |
Conforms |
Method: AUV305A |
|
ORAChydro |
>23,000 μM TE/g |
> 29,700 μM TE/g |
Conforms |
J. Agric.
Food Chem. 2001;
49(10), 4619-4626 |
|
Solubility |
DMSO, aqueous alkaline solutions, Ethanol, Ethers |
DMSO, aqueous alkaline solutions, Ethanol, Ethers |
Conforms |
ChemIDplus, US National Library of Medicine (NLM) monograph http://www.chemindustry.com/chemicals/783153.html |
|
Log P(octanol-water) |
Value = 0.95 |
Value = 0.95 |
Conforms |
ChemIDplus, US National Library of Medicine (NLM) monograph http://www.chemindustry.com/chemicals/783153.html |
|
Water Solubility |
2.20E+04 mg/L at 250C |
>2.20E+04 mg/L at 250C |
Conforms |
ChemIDplus, US National Library of Medicine (NLM) monograph http://www.chemindustry.com/chemicals/783153.html |
|
Water Solubility@900C |
80% |
>80% |
Conforms |
IP |
|
Stability |
This
product is stable for 2 years as supplied if, stored at +4°C up to 20 0C, and
protected from light. |
2 years |
Conforms |
Manufacture
- In accordance with expertise conclusion by Institute of Nutrition of
Russian Academy of Medicine Sciences issued on November 16th, 2006 |
|
Moisture |
0.5% |
0.4% |
Conforms |
|
|
Nutritive Content |
Protein – 0%, Carbohydrates, g/1g –
5%, Fat – 0% |
Protein – 0%, Carbohydrates, g/1g < 5%,
Fat – 0% |
Conforms |
Manufacture - In accordance with
expertise conclusion by Institute of Nutrition of Russian Academy of Medicine
Sciences issued on November 16th, 2006 |
GENERAL INFORMATION |
||||
Name |
DIHYDROQUERCETIN Synonyms: (+)-Dihydroquercetin;
(+)-Taxifolin; Taxifolin; trans-Dihydroquercetin; IUPAC Name: (2R,3R
)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one Systematic Name: (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-1-benzopyran-4-one. |
|||
INCI name |
Dihydroquercitin |
|||
Molecular
Formula |
C15H12O7 |
|||
Molecular
Weight, g/mol |
304.0583 |
|||
CAS Number |
480-18-2
System Generated
Number: 000480182 |
|||
EINECS Number |
207-543-4 |
|||
FDA Number |
54YCZ07 |
|||
RTECS |
LK6920000 |
|||
Botanical
Source |
Not genetically modified plant: Larch
species: L. dahurica L., L.
gmelinii, L. sibirica ledeb. Used part: sawlogs. Preparation: Spray dried
extract |
|||
Extraction process |
The
patented extraction process chain uses food grade ethanol and water as
solvents in a multistep process. The purified aqueous extract is spray dried
and represents fine, yellowish-colored powder with an aromatic smell and mild
bitter taste. |
|||
Sterilization |
DIHYDROQUERCETIN
is not subject of sterilization and radiation |
|||
Contact with GMO material |
None:
Manufacturer does not process any GMO modified material |
|||
Long Term Storage: |
At +4 0C
up to 20 0C
|
|||
Stability |
This
product is stable for 2 years as manufactured |
|||
Handling |
Protect
from light, store in a dry, cool place |
|||
DESCRIPTORS |
||||
Density |
1.182142759 |
Potential
energy (kcal/mol) |
73.8359227 |
|
Number of
rings |
3 |
Number of
atoms |
34 |
|
Chiral
atoms |
2 |
Acidic atoms |
0 |
|
H-bond
donor |
5 |
H-bond acceptor |
7 |
|
Basic atoms |
0 |
Aromatic atoms |
12 |
|
Heavy atoms |
22 |
Number of
bonds |
36 |
|
Single
bonds |
23 |
Rotatable single bonds |
1 |
|
Double
bonds |
0 |
Triple
bonds |
0 |
|
Aromatic
bonds |
12 |
Topological Polar Surface Area |
128 |
|
λmax |
A solution
in ethanol R shows an absorption maximum (2.2.25) at 290 nm and
at 340 nm |
|||
Product Specific References |
||||
Botanical
functions |
DIHYDROQUERCETIN
is a key dihydroflavonol intermediate between FLAVONOLS and FLAVANOLIGNINS.
An NADPH-dependent dihydroflavonol 4-reductase catalyses the formation of
leucocyanidin (Flavan 3,4-diol) structure. |
|||
Product
Description |
Antioxidant
bioflavonoid. Metal chelator. ORAChydro is over 28,000 μM TE/g |
|||
Major uses: |
Dihydroquercetin,
a yellowish crystalline pentahydroxy-flavanone, occurring in large quantities
in Larix species, Douglas fir and Jeffrey pine barks, was found to be an
effective antioxidant for lard, cottonseed oil, and butter oil. This compound
imparts no taste and color to fats and oils and appears to be nontoxic. Dihydroquercetin is the
non-nutrient antioxidant, relating to flavonoids, which occur in food and
which may be significant in the overall antioxidative protection afforded by
the diet. This benefit may be conferred in three main ways: (1) As antioxidant in
food during storage and in the gastrointestinal tract; (2) As antioxidants in
the human body; (3) By providing
protection in food against oxidation as well as acting as true antioxidant. |
|||
Environment |
Larch forests growing in |
|||
Product
Specific Literature References |
Interaction
of flavonoids with ascorbate and determination of their univalent redox
potentials: a pulse radiolysis study: Suppression
of active oxygen-induced cytotoxicity by flavonoids: T. Nakayama, et al.; Biochem. Pharmacol. 45,
265 (1993) Structure-antioxidant
activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. &
Med. 20, 933 (1996), (Review) |
Delivery to EU countries - up to 40 working days, other countries - up to 45 working days from receipt of the payment.
Dihydroquercetin (Taxifolin) CAS # 480-18-2
Dihydroquercetin (Taxifolin) for Cosmetics CosIng: EINECS/ELINCS # 207-543-4