96% Dihydroquercetin (Taxifolin) EUR/kg

ITEM

SPECIFICATION

ANALYSIS RESULT

CONFORMITY

ANALYSIS REFERENCE SOURCE

Appearance, Color, Odor, Taste

Light yellow solid crystalline powder, characteristic aromatic odor, astringent

Yellowish, fine crystalline powder, characteristic aromatic odor, mild bitter with sweetly aftertaste

Conforms

By Manufacture – Visual, Organoleptic

Particle size

NLT 90% (through 80 mesh)

NLT 90% (through 80 mesh)

Conforms

80 mesh screen / USP/NF<429>

Bulk Density

0.3 to 0.6

0.3 to 0.6

Conforms

USP/NF<699>

Characteristic Values

Over 85% Dihydroquercetin

 Over 85% Dihydroquercetin

Conforms

HPLC system with reversed phase column and UV detector is used for peak separation and quantitation. Journal of chromatography, 605: pp. 41-48 (1992)

Assay (HPLC λmax _{290 nm, retention time 9-11 minutes})

94-96%

95.89%

Conforms

Method:  ALC114A

Assay (HPLC λmax _{340 nm, retention time 9-11 minutes})

92%

92.10%

Conforms

Method: ALC114A

Other Flavonoids: Dihydrokaempferol, Quercetin,  Naringenin (HPLC λmax _{290 nm})

<10%

Total: 3.96% (Dihydrokaempferol-3,5%, Quercetin -0.5%, Naringenin – 0.1%

Method: ALC114A

Total saponins (UV-Vis)

(triterpene glycosides)

<10%

1,3 %

Conforms

Method: AUV305A

ORAC_hydro

>23,000 μM TE/g

> 29,700 μM TE/g

Conforms

J. Agric. Food Chem. 2001; 49(10), 4619-4626

Solubility

DMSO, aqueous alkaline solutions, Ethanol, Ethers

DMSO, aqueous alkaline solutions, Ethanol, Ethers

Conforms

ChemIDplus, US National Library of Medicine (NLM) monograph

http://www.chemindustry.com/chemicals/783153.html

Log P(octanol-water)

Value = 0.95

Value = 0.95

Conforms

ChemIDplus, US National Library of Medicine (NLM) monograph

http://www.chemindustry.com/chemicals/783153.html

Water Solubility

2.20E+04 mg/L at 25⁰C

>2.20E+04 mg/L at 25⁰C

Conforms

ChemIDplus, US National Library of Medicine (NLM) monograph

http://www.chemindustry.com/chemicals/783153.html

Water Solubility@90⁰C

80%

>80%

Conforms

IP

Stability

This product is stable for 2 years as supplied if, stored at +4°C up to  20 ⁰C, and protected from light.

2 years

Conforms

Manufacture - In accordance with expertise conclusion by Institute of Nutrition of Russian Academy of Medicine Sciences issued on November 16^th, 2006

Moisture

0.5%

0.4%

Conforms

Nutritive Content

Protein – 0%,

Carbohydrates, g/1g – 5%,

Fat – 0%

Protein – 0%, Carbohydrates, g/1g < 5%, Fat – 0%

Conforms

Manufacture - In accordance with expertise conclusion by Institute of Nutrition of Russian Academy of Medicine Sciences issued on November 16^th, 2006

GENERAL   INFORMATION

Name

DIHYDROQUERCETIN                                                                                                                                                 Synonyms: (+)-Dihydroquercetin; (+)-Taxifolin; Taxifolin; trans-Dihydroquercetin;                                                             (2R,3R)-Dihydroquercetin; (2R,3R)-3,3',4',5,7-Pentahydroxyflavanone

IUPAC Name: (2R,3R )-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one

Systematic Name: (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-1-benzopyran-4-one.

INCI name

Dihydroquercitin

Molecular Formula

C15H12O7

Molecular Weight, g/mol

304.0583

CAS Number

480-18-2                                                                                                                           System Generated Number:  000480182

EINECS Number

207-543-4

FDA Number

54YCZ07  

RTECS

LK6920000

Botanical Source

Not genetically modified plant: Larch species:  L. dahurica L., L. gmelinii, L. sibirica ledeb.

Used part: sawlogs. Preparation: Spray dried extract

Extraction process

The patented extraction process chain uses food grade ethanol and water as solvents in a multistep process. The purified aqueous extract is spray dried and represents fine, yellowish-colored powder with an aromatic smell and mild bitter taste.

Sterilization

DIHYDROQUERCETIN is not subject of sterilization and radiation

Contact with GMO material

None: Manufacturer does not process any GMO modified material

Long Term Storage:

At +4 ⁰C up to 20 ⁰C                                                                              

Stability

This product is stable for 2 years as manufactured

Handling

Protect from light, store in a dry, cool place

DESCRIPTORS

Density

1.182142759

Potential energy (kcal/mol)

73.8359227

Number of rings

3

Number of atoms

34

Chiral atoms

2

Acidic atoms

0

H-bond donor

5

H-bond acceptor

7

Basic atoms

0

Aromatic atoms

12

Heavy atoms

22

Number of bonds

36

Single bonds

23

Rotatable single bonds

1

Double bonds

0

Triple bonds

0

Aromatic bonds

12

Topological Polar Surface Area

128

λmax

A solution in ethanol R shows an absorption maximum (2.2.25) at 290 nm and at 340 nm

Product Specific References

Botanical functions

DIHYDROQUERCETIN is a key dihydroflavonol intermediate between FLAVONOLS and FLAVANOLIGNINS. An NADPH-dependent dihydroflavonol 4-reductase catalyses the formation of leucocyanidin (Flavan 3,4-diol) structure.

Product Description

Antioxidant bioflavonoid. Metal chelator. ORAC_hydro is over 28,000 μM TE/g

Major uses:  

Dihydroquercetin, a yellowish crystalline pentahydroxy-flavanone, occurring in large quantities in Larix species, Douglas fir and Jeffrey pine barks, was found to be an effective antioxidant for lard, cottonseed oil, and butter oil. This compound imparts no taste and color to fats and oils and appears to be nontoxic. Dihydroquercetin is the non-nutrient antioxidant, relating to flavonoids, which occur in food and which may be significant in the overall antioxidative protection afforded by the diet. This benefit may be conferred in three main ways:

(1) As antioxidant in food during storage and in the gastrointestinal tract;

(2) As antioxidants in the human body;

(3) By providing protection in food against oxidation as well as acting as true antioxidant.

Environment

Larch forests growing in Siberia and Russian Far East are recognized to be of very high bio-spheric and ecological importance worldwide. They establish both the southern and the northern timberlines and carry out water- and soil conservation functions in mountain regions as well as being regarded as a large carbon sink. The vast geographical area of Larix dahurica and Larix sibirica shows the large ecological plasticity of this species and its high adaptability to the different natural conditions found in the boreal Eurasian zone and in transition to typical temperate forests.

Product Specific Literature References

Interaction of flavonoids with ascorbate and determination of their univalent redox potentials: a pulse radiolysis study: W. Bors, et al.; Free Radic. Biol. Med. 19, 45 (1995) 19, 45. 

Suppression of active oxygen-induced cytotoxicity by flavonoids: T. Nakayama, et al.; Biochem. Pharmacol. 45, 265 (1993)

Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review)